RECHERCHE ETUDE Les tentatives de suicide chez les enfants et les adolescents: la place des gènes de l'horloge et le dysfonctionnement du rythme précoce

Titre original : Suicide attempts in children and adolescents: The place of clock genes and early rhythm dysfunction
Bertrand Olliac a, b, , , Lisa Ouss c, , Annaëlle Charrier d,

^a Pôle Universitaire de Psychiatrie de l'enfant et de l'adolescent, Centre Hospitalier Esquirol, 15 rue du docteur Marcland, 87025 Limoges, France
^b Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1094, Tropical Neuroepidemiology, Université de Limoges, Limoges, France
^c Department of Child and Adolescent Psychiatry, Necker-Enfants-Malades Hospital, APHP, Université Paris Descartes, 149 rue de Sèvres, 75015 Paris, France
^d Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent (PHUPEA), Université de Rennes 1, Centre Hospitalier Guillaume-Régnier, 154 Rue de Châtillon, 35000 Rennes, France

Journal of Physiology-Paris Available online 15 November 2017

Highlights
Early trauma and stressful life events can alter the expression of clock genes.
Alteration of clock genes might lead to desynchronized and abnormal circadian rhythms impairments.
Altered clock genes could participate in rhythm abnormalities and the emergence of suicide attempts.

Abstract
Suicide remains one of the leading causes of death among young people, and suicidal ideation and behavior are relatively common in healthy and clinical populations. Suicide risk in childhood and adolescence is often approached from the perspective of nosographic categories to which predictive variables for suicidal acts are often linked. The cascading effects resulting from altered clock genes in a pediatric population could participate in biological rhythm abnormalities and the emergence of suicide attempts through impaired regulation of circadian rhythms and emotional states with neurodevelopmental effects. Also, early trauma and stressful life events can alter the expression of clock genes and contribute to the emergence of suicide attempts. Alteration of clock genes might lead to desynchronized and abnormal circadian rhythms impairing in turn the synchronization between external and internal rhythms and therefore the adaptation of the individual to his/her internal and external environment with the development of psychiatric disorders associated with increased risk for suicide attempts.

http://www.sciencedirect.com/science/article/pii/S0928425717300591