jeudi 14 octobre 2021

ETUDE RECHERCHE Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)

Violent suicide attempt history in elderly patients with bipolar disorder: The role of sex, abdominal obesity, and verbal memory: Results from the FACE-BD cohort (FondaMental Advanced center of Expertise for Bipolar Disorders)
Aiste Lengvenyte 1, 2, 3, 4, * Bruno Aouizerate 3, 5 Valerie Aubin 6 Joséphine Loftus 3, 6 Emeline Marlinge 3, 7 Raoul Belzeaux 8, 3, 9 Caroline Dubertret 3, 10, 11 Sebastien Gard 3, 5 Emmanuel Haffen 3, 12, 13 Raymund Schwan 3, 14 Pierre-Michel Llorca 3, 15 Christine Passerieux 3, 16, 17 Paul Roux 3, 18 Mircea Polosan 3, 16, 17 Bruno Etain 3, 7 Marion Leboyer 3, 18 Philippe Courtet 3, 2, 1 Emilie Olié 3, 2, 1
* Auteur correspondant
1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 IGF - Institut de Génomique Fonctionnelle
3 Fondation FondaMental [Créteil]
4 Vilnius University [Vilnius]
5 Hôpital Charles Perrens
6 Hôpital Princesse Grace [Monaco]
7 Hôpital Lariboisière-Fernand-Widal [APHP]
8 INT - Institut de Neurosciences de la Timone
9 APHM - Assistance Publique - Hôpitaux de Marseille
10 Hôpital Louis Mourier - AP-HP [Colombes]
11 UP - Université de Paris
12 UFC - Université de Franche-Comté
13 CICB - Centre d'Investigation Clinique de Besançon
14 UL - Université de Lorraine
15 NPsy-Sydo - Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux
16 CHV - Centre Hospitalier de Versailles André Mignot
17 Université Paris-Saclay
18 IMRB - Institut Mondor de Recherche Biomédicale
Abstract : Background: Bipolar disorder (BD) is a chronic, lifelong condition, associated with increased risk of obesity, cognitive impairment, and suicidal behaviors. Abdominal obesity and a higher risk of violent suicide attempt (SA) seem to be shared correlates with older age, BD, and male sex until middle age when menopause-related female body changes occur. This study aimed at assessing the role of abdominal obesity and cognition in the violent SA burden of individuals with BD. Methods: From the well-defined nationwide cohort FACE-BD (FondaMental Advanced center of Expertise for Bipolar Disorders), we extracted data on 619 euthymic BD patients that were 50 years or older at inclusion. Cross-sectional clinical, cognitive, and metabolic assessments were performed. SA history was based on self-report. Results: Violent SA, in contrast to non-violent and no SA, was associated with higher waist circumference, abdominal obesity and poorer California Verbal Learning Test short-delay free recall (CVLT-SDFR) (ANOVA, p < .001, p = .014, and p = .006). Waist circumference and abdominal obesity were associated with violent SA history independently of sex, BD type and anxiety disorder (Exp(B) 1.02, CI 1.00-1.05, p = .018; Exp(B) 2.16, CI 1.00-4.64, p = .009, accordingly). In an exploratory model, waist circumference and CVLT-SDFR performance mediated the association between male sex and violent SA. Limitations: Cross-sectional design and retrospective reporting. Conclusions: Violent SA history was associated with abdominal obesity and poorer verbal memory in older age BD patients. These factors were interlinked and might mediate the association between male sex and violent SA.
https://hal.archives-ouvertes.fr/hal-03374307
Soumis le : mardi 12 octobre 2021 -

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