jeudi 12 novembre 2020

ETUDE RECHERCHE A comprehensive model of predictors of suicide attempt in individuals with panic disorder: Results from a national 3-year prospective study

A comprehensive model of predictors of suicide attempt in individuals with panic disorder: Results from a national 3-year prospective study

Valentin Scheer 1 Carlos Blanco 2 Mark Olfson 3 Cédric Lemogne 1, 4, 5 Guillaume Airagnes 1, 6 Hugo Peyre 7, 8 Frédéric Limosin 1, 4, 5 Nicolas Hoertel 1, 4, 5
1 Service de Psychiatrie et d'Addictologie de l'adulte et du sujet âgé [DMU Psychiatrie et Addictologie]
2 National Institute on Drug Abuse [Bethesda]
3 Columbia University [New York]
4 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
5 UPD5 - Université Paris Descartes - Paris 5
6 CONSTANCES - Cohortes épidémiologiques en population
7 Child and Adolescent Psychiatry Department [AP- HP Hôpital Robert Debré]
8 ENS Paris - École normale supérieure - Paris
General Hospital Psychiatry Volume 67, November–December 2020, Pages 127-135

Abstract
: Objective: People with panic disorder are at increased risk of suicide. Multiple factors influence their risk suggesting a need to combine them into an integrative model to develop more effective suicide prevention strategies for this population. In this report, we sought to build a comprehensive model of the 3-year risk of suicide attempt in individuals with panic disorder using a longitudinal nationally representative study, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC; wave 1, 2001-2002; wave 2, 2004-2005). Method: We used structural equation modeling to simultaneously examine effects of six broad groups of clinical factors previously identified as potential predictors of suicide attempt in adults with panic disorder: 1) severity of panic disorder, 2) severity of comorbidity, 3) prior history of suicide attempt, 4) family history of psychiatric disorders, 5) sociodemographic characteristics and 6) treatment-seeking behavior. Results: The 3-year prevalence rate of suicide attempt was 4.6%. A general psychopathology factor, lower physical health-related quality of life, prior suicide attempt and a greater number of stressful life events at baseline significantly and independently predicted suicide attempt between the two waves (p < .05). R-square of the models ranged from 0.47 to 0.50. Conclusion: This model may help inform future research and identify high-risk individuals among adults with panic disorder.