Titre original "ABCB1 gene polymorphisms and violent suicide attempt among survivorsJournal of Psychiatric Research
Volume 61, February 2015, Pages 52–56
E. Peñas-Lledóa, , , S. Guillaumeb, c, d, A. Delgadoa, M.E.G. Naranjoa, I. Jaussentc, d, A. LLerenaa, e, P. Courtetb, c, d
a CICAB Clinical Research Center, Extremadura University Hospital & Medical School, Badajoz, Spain
b CHU Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post Acute Care Department, Pole Urgence, Montpellier, France
c Inserm, U1061 Montpellier, Université Montpellier I, Montpellier, F-34000, France
d FondaMental Foundation, France
e CIBERSAM, Instituto de Salud Carlos III, Spain
Received 20 August 2014, Revised 9 November 2014, Accepted 5 December 2014, Available online 15 December 2014
The T allele in the three most common ABCB1 SNPs was most frequent among individuals who dead by using violent suicide methods.•
Present result show a higher frequency of suicide attempters using violent methods among ABCB1 haplotype (1236TT-2677TT-3435 TT) carriers.•
This ABCB1 haplotype increased the risk more than three times among women attempting a violent suicide for the first time.
Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for P-gp. Thus, this study examined, for the first time, whether these ABCB1 SNPs were associated with the use of violent means among survivors of a suicide attempt.
Material and methods
Suicide attempters (n = 578, 87.4% women; of whom 16.6% committed a violent intent) were genotyped for exonic SNPs in the ABCB1 (C1236T, G2677T/A, C3435T). The relations of the three genotypes and of the TTT haplotype with the use of a violent suicide method were evaluated separately. The impact of confounds on these variables was controlled.
A higher frequency (p = 0.02) of suicide attempters using violent methods was found among those carrying the ABCB1 haplotype (1236TT-2677TT-3435TT). Since gender and number of previous suicide attempts were identified as confounds, the relation was tested in the subset of women who were first-time attempters or second- and more-time attempters. The ABCB1 haplotype increased the risk more than three times in those women attempting a violent suicide for the first time (OR = 3.6; CI95%: 1.08–12.09; p = 0.04).
The ABCB1 haplotype (1236TT-2677TT-3435TT) was related to the use of a violent suicide attempt method. Genotyping for these three ABCB1 SNPs may be helpful to detect people at risk of first suicide intents using violent methods.
Violent suicide methods;
Corresponding author. Facultad de Medicina, Universidad de Extremadura, Av del Elvas s/n Badajoz 06071, Spain. Tel.: +34 924218040; fax: +34 924219881.