vendredi 27 février 2015

RECHERCHE CANADA FRANCE USA : Inhibition cognitive dans les tentatives de suicide à haute létalité des âgés

Cognitive inhibition in older high-lethality suicide attempters
Stéphane Richard-Devantoy1,2,  Katalin Szanto3,  Meryl A. Butters3,  Jan Kalkus3 and
Alexandre Y. Dombrovski3,*
Article first published online: 12 MAY 2014
International Journal of Geriatric Psychiatry Volume 30, Issue 3, pages 274–283, March 2015
1 Department of Psychiatry and Douglas Mental Health University Institute, McGill Group for Suicide Studies, McGill University, Montréal, Québec, Canada
Laboratoire de Psychologie des Pays de la Loire EA 4638, Université de Nantes et Angers, France
Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
*Correspondence to: A. Y. Dombrovski. E-mail:

Background People who attempt suicide often display cognitive impairments, particularly poor cognitive control. Could poor cognitive control contribute to high suicide rates in old age? A component of cognitive control, cognitive inhibition—active suppression of task-irrelevant processing—is very sensitive to aging and has been linked to attempted suicide. We investigated cognitive inhibition in older high-lethality suicide attempters, closely resembling suicide victims, as well as low-lethality attempters, and control groups with and without depression and suicidal ideation.
Methods A total of 102 participants aged 60 years and older (17 psychiatrically healthy control subjects, 38 depressed control subjects, 16 suicide ideators, 14 low-lethality suicide attempters, and 17 high-lethality suicide attempters) underwent comprehensive clinical and cognitive assessments. They completed the Delis–Kaplan Executive Function System Color-Word Interference Test, a validated modification of the Stroop test.
Results High-lethality suicide attempters demonstrated a distinct pattern of cognitive inhibition deficits. Compared with psychiatrically healthy control subjects and suicide ideators, high-lethality attempters took longer to complete inhibition trials, even after accounting for potential confounding factors (age, education, Mini mental state examination score, information processing speed, and accuracy). Compared with non-suicidal depressed and healthy control subjects, low-lethality suicide attempters committed more uncorrected errors; however, this difference was not specific to the inhibition condition.
Conclusions Older suicide attempters are a cognitively heterogeneous group. Poor cognitive control in high-lethality attempters may undermine their ability to solve real-life problems, precipitating a catastrophic accumulation of stressors. Meanwhile, low-lethality attempters' poor performance may reflect a careless approach to the task or faulty monitoring.

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