lundi 13 mai 2024

ETUDE RECHERCHE Risk factors of suicide re-attempt: A two-year prospective study

Article Dans Une Revue Journal of Affective Disorders Année : 2024

Risk factors of suicide re-attempt: A two-year prospective study
B. Nobile (1, 2, 3) , I. Jaussent (4) , J.P. Kahn (5, 3) , M. Leboyer (3, 6, 7, 8) , N. Risch (2) , E. Olié (1, 2, 3) , Ph. Courtet (1, 2, 3)
1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
2 IGF - Institut de Génomique Fonctionnelle
3 Fondation FondaMental [Créteil]
4 INM - Institut des Neurosciences de Montpellier
5 UL - Université de Lorraine
6 IMRB - Institut Mondor de Recherche Biomédicale
7 Hôpital Henri Mondor
8 FHU ADAPT - Fédération Hospitalo-Universitaire de Médecine de Précision en Psychiatrie [Créteil]


Background: History of suicide attempt (SA) is the strongest predictor of a new SA and suicide. It is primordial to identify additional risk factors of suicide re-attempt. The aim of this study was to identify risk factors of suicide re-attempt in patients with recent SA followed for 2 years. Methods: In this multicentric cohort of adult inpatients, the median of the index SA before inclusion was 10 days. Clinicians assessed a large panel of psychological dimensions using validated tools. Occurrence of a new SA or death by suicide during the follow-up was recorded. A cluster analysis was used to identify the dimensions that best characterized the population and a variable "number of personality traits" was created that included the three most representative traits: anxiety, anger, and anxious lability. Risk factors of re-attempt were assessed with adjusted Cox regression models. Results: Among the 379 patients included, 100 (26.4 %) re-attempted suicide and 6 (1.6 %) died by suicide. The two major risk factors of suicide re-attempt were no history of violent SA and presenting two or three personality traits among trait anxiety, anger and anxious lability. Limitations: It was impossible to know if treatment change during follow-up occur before or after the re-attempt. Discussion: One of the most important predictors of re-attempt in suicide attempters with mood disorders, was the presence of three personality traits (anger, anxiety, and anxious lability). Clinicians should provide close monitoring to patients presenting these traits and proposed treatments specifically targeting these dimensions, especially anxiety.

Mots clés

Anger Anxiety Anxious lability Re-attempt Suicide Suicide attempt

Soumis le : lundi 6 mai 2024-17:50:15

Dernière modification le : lundi 13 mai 2024-11:32:34

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B. Nobile, I. Jaussent, J.P. Kahn, M. Leboyer, N. Risch, et al.. Risk factors of suicide re-attempt: A two-year prospective study. Journal of Affective Disorders, 2024, 356, pp.535-544. ⟨10.1016/j.jad.2024.04.058⟩. ⟨hal-04570038⟩