Mixed Features and Nonfatal Suicide Attempt Among Individuals With Major Depressive Episode: Insights From the French MHGP Survey
Hugo Peyre 1 2 3 , Nicolas Hoertel 4 5 6 , Baptiste Pignon 7 , Ali Amad 8 9 , Jean-Luc Roelandt 10 , Imane Benradia 10 , Pierre Thomas 8 9 , Guillaume Vaiva 8 9 11 , Pierre-Alexis Geoffroy 12 13 14 , Emilie Olié 15 16 17 , Philippe Courtet 15 16 17
Affiliations
1 Centre de Ressource Autisme Languedoc-Roussillon et Centre d'Excellence Sur l'Autisme et les Troubles du Neurodéveloppement (CeAND), CHU Montpellier, Montpellier, France.
2 Université Paris-Saclay, UVSQ, Inserm, CESP, Team DevPsy, Villejuif, France.
3 Corresponding Author: Hugo Peyre, MD, PhD, CHU Montpellier, 291 Ave du Doyen Giraud, 34295 Montpellier Cedex 5, France (hugo.peyre@chu-montpellier.fr).
4 Department of Psychiatry, AP-HP Centre, DMU Psychiatrie et Addictologie, Corentin-Celton Hospital, Issy-les-Moulineaux, France.
5 INSERM 1266, Psychiatry and Neurosciences Center, Paris, France.
6 Université Paris Cité, Paris, France.
7 Université Paris Est Créteil, INSERM, IMRB, AP-HP, Hôpitaux Universitaires H. Mondor, DMU IMPACT, Fondation FondaMental, Créteil, France.
8 Lille Neurosciences and Cognition, Lille University Hospital, University of Lille, and National Institute of Health and Medical Research, U1172, Lille, France.
9 Fédération Régionale de Recherche en Santé Mentale (F2RSM) Hauts-de-France, Lille, France.
10 EPSM Lille Métropole; Centre Collaborateur de l'Organisation Mondiale de la Santé pour la Recherche et la Formation en Santé Mentale; Équipe Eceve Inserm UMR 1123, Hellemmes, France.
11 Centre National de Ressources & Résilience (Cn2r Lille-Paris), Lille, France.
12 Département de Psychiatrie et d'Addictologie, AP-HP, GHU Paris Nord, DMU Neurosciences, Hopital Bichat-Claude Bernard, Paris, France.
13 Centre ChronoS, GHU Paris-Psychiatry and Neurosciences, Paris, France.
14 NeuroDiderot, Inserm, Université Paris Cité, Paris, France.
15 Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, Montpellier, France.
16 Department of Emergency Psychiatry and Post-Acute Care, CHU Montpellier, Montpellier, France.
17 Fondation FondaMental, Créteil, France.
PMID: 39508717
DOI: 10.4088/JCP.24m15445
J Clin Psychiatry
. 2024 Nov 6;85(4):24m15445. doi: 10.4088/JCP.24m15445.
Abstract
Background: This study explores among individuals with a major depressive episode (MDE) the potential impact of mixed features on the risk of suicide attempt, suicidal thoughts, self-harm intentions, and thoughts of death.
Methods: Data from the French Mental Health in General Population (MHGP) survey (1999-2003) were analyzed, including 128 participants meeting DSM 5 criteria for MDE with mixed features (MDE with at least 3 manic symptoms) and 3,312 participants experiencing MDE without mixed features. Our primary analysis focused on suicide attempt, with additional examination of recent suicidal thoughts, self-harm intentions, and thoughts of death. Multivariable regression models were performed to adjust for potential confounding variables, including sociodemographics, previous suicide attempt, number of depressive symptoms, and psychiatric comorbidity.
Results: MDE with mixed features was significantly associated with an increased risk of suicide attempt (adjusted odds ratio [AOR] = 1.69; 95% CI, 1.26-2.25). This association did not significantly differ between men and women. Furthermore, the number of manic symptoms demonstrated a dose-dependent relationship with an increased risk of suicide attempt (AOR = 1.18; 95% CI, 1.07-1.30; P < .001). Mixed features were also associated with suicide attempt among individuals with MDE and without recent suicidal thoughts (AOR = 2.74; 95% CI, 1.36-5.54).
Conclusion: This study underscores the importance of assessing mixed features when evaluating the risk of suicide attempt in individuals with MDE. Mechanisms underlying this association might be independent of progression from thoughts of death to suicidal thoughts, suicidal intention, and ultimately, suicide attempt.
lundi 25 novembre 2024
ETUDE RECHERCHE Mixed Features and Nonfatal Suicide Attempt Among Individuals With Major Depressive Episode: Insights From the French MHGP Survey
