lundi 21 novembre 2016

ETUDE RECHERCHE L'intégrité du Corpus callosum est affectée par les troubles de l'humeur et aussi par l'histoire de la tentative de suicide: Une étude d'imagerie du tenseur de diffusion

Titre original Corpus callosum integrity is affected by mood disorders and also by the suicide attempt history: A diffusion tensor imaging study

Fabienne Cyprien a, b, c, Nicolas Menjot de Champfleur b, c, Jérémy Deverdun b, c, d, Emilie Olié a, b, c, Emmanuelle Le Bars c, Alain Bonafé b, c, Thibault Mura a, b, c, f, Fabrice Jollant g, h, Philippe Courtet a, b, c, e, , Sylvaine Artero a, b, ,
a
Inserm, U1061, La Colombière Hospital, Montpellier F-34093, France
b University of Montpellier, Montpellier F-34000, France
c CHRU Montpellier, Montpellier F-34093, France
d CNRS, UMR 5221, Montpellier F-34093, France
e Fondamental Foundation, France
f CIC 1001, Montpellier F-34000, France
g McGill University, Department of Psychiatry, Canada
h Douglas Mental Health University Institute, McGill Group for Suicide Studies, Montréal, Québec, Canada
 
Journal of Affective Disorders
Volume 206, December 2016, Pages 115–124

Highlights•
Corpus callosum (CC) is altered in bipolar disorders (BD).•
Genu and body CC areas are altered in BD without suicide Attempt (SA).•
History of SA exerts also a specific effect on CC integrity.•
Splenium is specifically altered in SA independently from psychiatric status.•
Screening for history of SA is crucial in future analyses of CC in affective disorders.

Abstract
Background
Some MRI studies have noted alterations in the corpus callosum (CC) white matter integrity of individuals with mood disorders and also in patients with suicidal behavior. We investigated the specific impact of suicidal behavior on CC integrity in mood disorders.
Methods
CC structural changes were assessed by diffusion tensor imaging (DTI) in 121 women 18-50-year-old): 41 with bipolar disorder (BD), 50 with major depressive disorder (MDD) and 30 healthy controls (HC). Fractional anisotropy (FA) and DTI metrics were calculated for the genu, body and splenium of CC and compared in the three groups by MANCOVA. Then, they were re-analyzed relative to the suicide attempt history within the MDD and BD groups and to the suicide number/severity.
Results
FA values for the CC genu and body were lower in non-suicide attempters with BD than with MDD and in HC. Conversely, FA values for all CC regions were significantly lower in suicide attempters with BD than in HC. Finally, higher number of suicide attempts (>2) and elevated Suicidal Intent Scale score were associated with significant splenium alterations.
Limitations
Limitations include the cross-sectional design (non-causal study), the potential influence of medications and concerns about the generalizability to men.
Conclusion
Genu and body are altered in non-suicide attempters with BD, while splenium is specifically altered in suicide attempters, independently from their psychiatric status. History of suicide attempts may be a source of heterogeneity in the association between CC alterations and BD and may partially explain the variable results of previous studies.
http://www.jad-journal.com/article/S0165-0327(15)31135-6/abstract

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