ETUDE RECHERCHE Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression

Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression

Benedicte Nobile ^{1, 2, *} Emilie Olie ^{1, 2, 3} Nicolas Ramoz ⁴ Jonathan Dubois ^{1, 2} Sebastien Guillaume ^{1, 2, 3} Philip Gorwood ⁴ Philippe Courtet ^{1, 2, 3}

* Auteur correspondant

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

2 IGF - Institut de Génomique Fonctionnelle

3 Fondation FondaMental [Créteil]

4 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris

Abstract : Background: Growing evidences suggest that depression with suicidal ideation (SI) could be a specific phenotype with its own characteristics. Moreover, opioid system deregulation might be implicated in suicidal behaviour (SB). The aim of this study was to determine whether the A118G polymorphism (rs1799971) in ORPM1 (the gene encoding opioid receptor mu 1) is associated with suicidal depression (ie, moderate to severe depression with SI) in a large cohort of outpatients with depression. Methods: GENESE is a large, prospective, naturalistic cohort of French adult outpatients with depression (DSM-IV criteria), treated and followed for 6 weeks. Depression severity was assessed with the Hospital Anxiety and Depression Scale (HADS), and SI with the suicidal item of the Montgomery-Åsberg Depression Rating Scale (MADRS-SI). From this cohort, patients with moderate or severe depression (HADS-D subscale score >11) were selected and classified as without SI (MADRS-SI < 2), or with SI (MADRS-SI ≥ 2). Results: The AA/AG genotypes of the A118G polymorphism were significantly associated with suicidal depression in the non-adjusted (OR = 2.32, 95% CI = [1.28; 4.18]; p-value = 0.005) and in the adjusted models (OR = 2.54, 95% CI = [1.35; 4.78]; p-value = 0.004). Conclusion: Outpatients with depression harbouring the A allele are at higher risk of SI (and possibly SB) than those carrying the G allele. More studies are needed to better understand the link between this polymorphism and SB.

Soumis le : jeudi 4 novembre 2021 - 11:49:02
Dernière modification le : vendredi 5 novembre 2021 - 04:23:03
Lien texte intégral https://www.dovepress.com/getfile.php?fileID=74926
Citation
Benedicte Nobile, Emilie Olie, Nicolas Ramoz, Jonathan Dubois, Sebastien Guillaume, et al.. Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression. Neuropsychiatric Disease and Treatment, Dove Medical Press, 2021, 17, pp.3109-3118. ⟨10.2147/NDT.S324868⟩. ⟨hal-03414253⟩

Source https://hal.archives-ouvertes.fr/hal-03414253