ETUDE RECHERCHE Characteristics and treatment outcome of suicidal depression: Two large naturalistic cohorts of depressed outpatients

Characteristics and treatment outcome of suicidal depression: Two large naturalistic cohorts of depressed outpatients

Bénédicte Nobile ^{1, 2} Emilie Olié ^{1, 2, 3} Jonathan Dubois ^{1, 2} Sebastien Guillaume ^{1, 2, 3} Philip Gorwood ⁴ Philippe Courtet ^{1, 2, 3}

1 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

2 IGF - Institut de Génomique Fonctionnelle

3 Fondation FondaMental [Créteil]

4 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris

Abstract : Objective: The emergence of new drugs for managing suicidal ideation (e.g. ketamine) raises the question of whether suicidal depression (i.e. moderate to severe depression with concomitant suicidal ideation) is a specific depression phenotype. Therefore, this study characterized patients with suicidal depression (baseline clinical characteristics, suicidal ideation and depression evolutions, suicide risk) in two large cohorts of outpatients with depression. Methods: LUEUR and GENESE are two large, prospective, naturalistic cohorts of French adult outpatients with depression (Diagnostic and Statistical Manual of Mental Disorders, fourth edition, criteria), treated and followed up for 6 weeks. Depression severity was assessed with the Hospital Anxiety and Depression Scale, and suicidal ideation with the suicidal item of the Montgomery-Åsberg Depression Rating Scale. Patients with moderate or severe depression (Hospital Anxiety and Depression Scale-Depression subscale score >11) were selected and classified as without suicidal ideation (suicidal item of the Montgomery-Åsberg Depression Rating Scale <2), with moderate suicidal ideation (suicidal item of the Montgomery-Åsberg Depression Rating Scale [2; 3]) and with severe suicidal ideation (suicidal item of the Montgomery-Åsberg Depression Rating Scale ⩾4). Results: Baseline clinical features were more severe (e.g. higher anxiety and depression scores) in depressed patients with moderate/severe suicidal ideation. Depression remission after treatment was less frequent among patients with severe suicidal ideation. The risk of suicide attempt during the follow-up was threefold higher in patients with suicidal ideation among those 10% had persistent suicidal ideation. Conclusion: Suicidal depression could be a specific depression phenotype with more severe clinical characteristics, less frequent depression remission, suicidalideation persistence and higher suicide attempt risk, despite antidepressant treatment. It seems that
Soumis le : mercredi 21 juillet 2021 - 15:28:44
Dernière modification le : vendredi 23 juillet 2021 - 03:15:43
Source https://hal.archives-ouvertes.fr/hal-03294347

Citation

Bénédicte Nobile, Emilie Olié, Jonathan Dubois, Sebastien Guillaume, Philip Gorwood, et al.. Characteristics and treatment outcome of suicidal depression: Two large naturalistic cohorts of depressed outpatients. Australian and New Zealand Journal of Psychiatry, SAGE Publications, 2021, pp.000486742110256. ⟨10.1177/00048674211025697⟩. ⟨hal-03294347⟩