The opioid system and the social brain: implications for depression and suicide
Abstract : In the past decade,
considerable attention has been drawn to social interactions and
behaviors as sources of pleasurable (social reward) and painful (social
pain) emotional states. While the role of the opioid system in the
regulation of reward and pain processes has long been recognized, it has
more recently been investigated and characterized in the specific
context of social experiences across several mammalian species.
Accordingly, the present narrative review provides a comprehensive
summary of studies detailing how the opioid system controls social
reward and social pain. From a translational and pathophysiological
perspective, we further discuss how opioid-dependent regulation of
social behaviors may contribute to depressive illness and suicidal
behaviors, and ultimately provide innovative therapeutic opportunities.
Soumis le : mercredi 16 octobre 2019 - 11:32:27
Source https://hal.umontpellier.fr/hal-02317670