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lundi 21 octobre 2019

ETUDE RECHERCHE The opioid system and the social brain: implications for depression and suicide

The opioid system and the social brain: implications for depression and suicide

Pierre-Eric Lutz 1, 2 Philippe Courtet 3, 4, 5 Raffaella Calati 3, 4, 5

1 INCI - Institut des Neurosciences Cellulaires et Intégratives

2 FMTS - Fédération de Médecine Translationnelle de Strasbourg

3 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]

4 Neuropsychiatrie : recherche épidémiologique et clinique

5 Fondation FondaMental [Créteil]


Abstract : In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has more recently been investigated and characterized in the specific context of social experiences across several mammalian species. Accordingly, the present narrative review provides a comprehensive summary of studies detailing how the opioid system controls social reward and social pain. From a translational and pathophysiological perspective, we further discuss how opioid-dependent regulation of social behaviors may contribute to depressive illness and suicidal behaviors, and ultimately provide innovative therapeutic opportunities.



Soumis le : mercredi 16 octobre 2019 - 11:32:27
Source https://hal.umontpellier.fr/hal-02317670