RECHERCHE ESPAGNE FRANCE :Polymorphismes du gène ABCB1 et tentative de suicide violente chez les survivants

Titre original "ABCB1 gene polymorphisms and violent suicide attempt among survivors

Journal of Psychiatric Research
Volume 61, February 2015, Pages 52–56

E. Peñas-Lledó^{a, ,} , S. Guillaume^{b, c, d}, A. Delgado^a, M.E.G. Naranjo^a, I. Jaussent^{c, d}, A. LLerena^{a, e}, P. Courtet^{b, c, d
a} CICAB Clinical Research Center, Extremadura University Hospital & Medical School, Badajoz, Spain
^b CHU Montpellier, Hôpital Lapeyronie, Psychiatric Emergency and Post Acute Care Department, Pole Urgence, Montpellier, France
^c Inserm, U1061 Montpellier, Université Montpellier I, Montpellier, F-34000, France
^d FondaMental Foundation, France
^e CIBERSAM, Instituto de Salud Carlos III, Spain
Received 20 August 2014, Revised 9 November 2014, Accepted 5 December 2014, Available online 15 December 2014

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Highlights•

The T allele in the three most common ABCB1 SNPs was most frequent among individuals who dead by using violent suicide methods.•

Present result show a higher frequency of suicide attempters using violent methods among ABCB1 haplotype (1236TT-2677TT-3435 TT) carriers.•

This ABCB1 haplotype increased the risk more than three times among women attempting a violent suicide for the first time.

Abstract
Introduction

Those suicide attempters that choose violent methods dramatically diminish the possibility of survival. Completed suicide using violent means, which is common among first-time suicide attempters, was recently found to be more likely among T allele carriers in the three most common ABCB1 SNPs, encoding for P-gp. Thus, this study examined, for the first time, whether these ABCB1 SNPs were associated with the use of violent means among survivors of a suicide attempt.
Material and methods

Suicide attempters (n = 578, 87.4% women; of whom 16.6% committed a violent intent) were genotyped for exonic SNPs in the ABCB1 (C1236T, G2677T/A, C3435T). The relations of the three genotypes and of the TTT haplotype with the use of a violent suicide method were evaluated separately. The impact of confounds on these variables was controlled.
Results

A higher frequency (p = 0.02) of suicide attempters using violent methods was found among those carrying the ABCB1 haplotype (1236TT-2677TT-3435TT). Since gender and number of previous suicide attempts were identified as confounds, the relation was tested in the subset of women who were first-time attempters or second- and more-time attempters. The ABCB1 haplotype increased the risk more than three times in those women attempting a violent suicide for the first time (OR = 3.6; CI95%: 1.08–12.09; p = 0.04).
Discussion

The ABCB1 haplotype (1236TT-2677TT-3435TT) was related to the use of a violent suicide attempt method. Genotyping for these three ABCB1 SNPs may be helpful to detect people at risk of first suicide intents using violent methods.
Keywords
Suicide attempt;
Violent suicide methods;
ABCB1

Corresponding author. Facultad de Medicina, Universidad de Extremadura, Av del Elvas s/n Badajoz 06071, Spain. Tel.: +34 924218040; fax: +34 924219881.

http://www.sciencedirect.com/science/article/pii/S002239561400346X